Structure of the Protein Phosphatase 2A Holoenzyme

Summary for 2NPP

Related2IE3 2IE4
Related PRD IDPRD_000212
DescriptorProtein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... (5 entities in total)
Functional Keywordsheat repeat, signaling protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P67775
Nucleus Q13362
Total number of polymer chains8
Total molecular weight309667.67
Xu, Y.,Chen, Y.,Xing, Y.,Chao, Y.,Shi, Y. (deposition date: 2006-10-28, release date: 2006-12-12, Last modification date: 2013-02-27)
Primary citation
Xu, Y.,Xing, Y.,Chen, Y.,Chao, Y.,Lin, Z.,Fan, E.,Yu, J.W.,Strack, S.,Jeffrey, P.D.,Shi, Y.
Structure of the protein phosphatase 2A holoenzyme
Cell(Cambridge,Mass.), 127:1239-1251, 2006
PubMed: 17174897 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2006.11.033
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267345.3%6.1%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution