2NPP
Structure of the Protein Phosphatase 2A Holoenzyme
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Protein Phosphatase 2, regulatory subunit A (PR 65), alpha isoform | polymer | 589 | 65378.3 | 2 | UniProt (Q96DH3) Pfam (PF02985) UniProt (by SIFTS) (P30153) | Homo sapiens (human) | Protein Phosphatase 2A |
| 2 | B, E (B, E) | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform | polymer | 449 | 52695.3 | 2 | UniProt (Q13362) Pfam (PF01603) | Homo sapiens (human) | PP2A, B subunit, B' gamma isoform; PP2A, B subunit, B56 gamma isoform; PP2A, B subunit, PR61 gamma isoform; PP2A, B subunit, R5 gamma isoform; NY-REN-29 antigen |
| 3 | C, F (C, F) | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 309 | 35636.2 | 2 | UniProt (P67775) Pfam (PF00149) | Homo sapiens (human) | serine/threonine protein phosphatase; PP2A-alpha; Replication protein C; RP-C |
| 4 | G, H (X, Y) | microcystin LR | polymer | 7 | 1014.2 | 2 | NOR (NOR00109) BIRD (PRD_000212) | Cyanobacteria | |
| 5 | I, J, K, L (C, F) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) |
Sequence modifications
B, E: -9 - 439 (UniProt: Q13362)
| PDB | External Database | Details |
|---|---|---|
| Val 433 | - | cloning artifact |
| Leu 434 | - | cloning artifact |
| Lys 435 | - | cloning artifact |
| Lys 436 | - | cloning artifact |
| Arg 437 | - | cloning artifact |
| Ile 438 | - | cloning artifact |
| Thr 439 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 309447.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 219.8 | |
| All* | Total formula weight | 309667.7 |
