2NP7

Crystal structure of the adenine-specific DNA methyltransferase M.TaqI complexed with the cofactor analog AETA and a 10 bp DNA containing an abasic site analog at the target position and pyrrolo-dC at the target base partner position

Summary for 2NP7

• Entry DOI: 10.2210/pdb2np7/pdb
• Related: 1AQI 1AQJ 1G38 2ADM 2IBS 2IBT 2IH2 2IH4 2IH5 2NP6
• Descriptor: 5'-D(*GP*TP*TP*CP*GP*(3DR)P*TP*GP*TP*C)-3', 5'-D(*GP*AP*CP*AP*(4PC)P*CP*GP*(6MA)P*AP*C)-3', Modification methylase TaqI, ... (6 entities in total)
• Functional Keywords: dna, dna methyltransferase, target base partner, pyrrolo-dc, abasic site analog, base flipping, nucleotide flipping, transferase-dna complex, transferase/dna
• Biological source: Thermus aquaticus; More
• Total number of polymer chains: 3
• Total formula weight: 54434.73

Authors

Lenz, T.,Scheidig, A.J.,Weinhold, E. (deposition date: 2006-10-26, release date: 2007-11-13, Last modification date: 2023-08-30)

• Primary citation: Lenz, T.,Scheidig, A.J.,Weinhold, E.; Caught in the act II: Visualization of an intermediate in the DNA base-flipping pathway induced by the adenine-specific DNA methyltransferase M.TaqI; To be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)