2NP7

Crystal structure of the adenine-specific DNA methyltransferase M.TaqI complexed with the cofactor analog AETA and a 10 bp DNA containing an abasic site analog at the target position and pyrrolo-dC at the target base partner position

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0006304	biological_process	DNA modification
A	0008168	molecular_function	methyltransferase activity
A	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
A	0009307	biological_process	DNA restriction-modification system
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. ILGNPPY

Chain	Residue	Details
A	ILE102-TYR108

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0007744|PDB:2ADM

Chain	Residue	Details
A	THR23
A	GLU45
A	GLU71
A	ASP89
A	PRO107

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0007744|PDB:2ADM

Chain	Residue	Details
A	ASN105
A	TYR108

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Important for catalytic activity; via amide nitrogen => ECO:0007744|PDB:2ADM

Chain	Residue	Details
A	PRO106

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 2adm

Chain	Residue	Details
A	PRO106
A	ASN105
A	TYR108

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 46

Chain

Residue

Details

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