Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2N96

An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A

Summary for 2N96
Entry DOI10.2210/pdb2n96/pdb
NMR InformationBMRB: 25882
DescriptorDNA (5'-D(*GP*CP*TP*AP*TP*AP*GP*C)-3'), (1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside (2 entities in total)
Functional Keywordsdiazofluorene, intercalator, dna
Biological sourcesynthetic construct
Total number of polymer chains2
Total formula weight6228.70
Authors
Woo, C.M.,Li, Z.,Paulson, E.,Herzon, S.B. (deposition date: 2015-11-07, release date: 2016-06-01, Last modification date: 2021-11-03)
Primary citationWoo, C.M.,Li, Z.,Paulson, E.K.,Herzon, S.B.
Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A.
Proc.Natl.Acad.Sci.USA, 113:2851-2856, 2016
Cited by
PubMed: 26929332
DOI: 10.1073/pnas.1519846113
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon