2N96

An unexpected mode of small molecule DNA binding provides the structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	X, Y	DNA (5'-D(*GP*CP*TP*AP*TP*AP*GP*C)-3')	polymer	8	2426.6	2		synthetic construct
2	Y	(1R,1'R,2S,2'S,3R,3'R,5aR,10aR,11a'S)-2'-[(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)oxy]-2,2'-diethyl-11,11 '-dihydrazinyl-6,6',9,9'-tetrahydroxy-4,4',5,5',10,10'-hexaoxo-1,1'-bis{[2,4,6-trideoxy-4-(dimethylamino)-beta-L-arabino -hexopyranosyl]oxy}[2,2',3,3',4,4',5,5',5a,8,10,10',10a,11a'-tetradecahydro-1H,1'H-[3,3'-bibenzo[b]fluorene]]-2-yl 2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranoside	non-polymer		1375.5	1	Chemie (4JF)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	4853.2
Non-Polymers*	Number of molecules	1
	Total formula weight	1375.5
All*	Total formula weight	6228.7

*Water molecules are not included.