2N8R

Productive complex between MMP-12 and synthetic triple-helical collagen, revealed through paramagnetic NMR

Summary for 2N8R

• Entry DOI: 10.2210/pdb2n8r/pdb
• Related: 2poj
• NMR Information: BMRB: 25859
• Descriptor: Macrophage metalloelastase, Collagen triple helix repeat family protein, ZINC ION, ... (5 entities in total)
• Functional Keywords: collagenolysis, matrix petalloproteinase, hydrolase-structural protein complex, hydrolase/structural protein
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix : P39900
• Total number of polymer chains: 4
• Total formula weight: 28360.81

Authors

Prior, S.H.,Van Doren, S.R. (deposition date: 2015-10-24, release date: 2016-02-24, Last modification date: 2016-04-27)

• Primary citation: Prior, S.H.,Byrne, T.S.,Tokmina-Roszyk, D.,Fields, G.B.,Van Doren, S.R.; Path to Collagenolysis: COLLAGEN V TRIPLE-HELIX MODEL BOUND PRODUCTIVELY AND IN ENCOUNTERS BY MATRIX METALLOPROTEINASE-12.; J.Biol.Chem., 291:7888-7901, 2016; PubMed: 26887942; DOI: 10.1074/jbc.M115.703124

Experimental method

SOLUTION NMR