2N7B

Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx

Summary for 2N7B

• Entry DOI: 10.2210/pdb2n7b/pdb
• Related: 2N7A
• NMR Information: BMRB: 25799
• Descriptor: Sialic acid-binding Ig-like lectin 8, N-acetyl-alpha-neuraminic acid-(2-3)-6-O-sulfo-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, 3-aminopropan-1-ol (3 entities in total)
• Functional Keywords: sialic acid-binding immunoglobulin-like lectin 8, siglec8, saf-2, i-type lectin, carbohydrate-binding receptor, carbohydrate recognition, protein-glycan complex, sulfated sialyl lewis x, structural protein
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q9NYZ4
• Total number of polymer chains: 1
• Total formula weight: 17641.38

Authors

Proepster, J.M.,Yang, F.,Rabbani, S.,Ernst, B.,Allain, F.H.-T.,Schubert, M. (deposition date: 2015-09-07, release date: 2016-07-06, Last modification date: 2020-07-29)

• Primary citation: Propster, J.M.,Yang, F.,Rabbani, S.,Ernst, B.,Allain, F.H.,Schubert, M.; Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.; Proc.Natl.Acad.Sci.USA, 113:E4170-E4179, 2016; PubMed: 27357658; DOI: 10.1073/pnas.1602214113

Experimental method

SOLUTION NMR