2N7B
Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Sialic acid-binding Ig-like lectin 8 | polymer | 145 | 16665.5 | 1 | UniProt (Q9NYZ4) Pfam (PF07686) In PDB | Homo sapiens (human) | Siglec-8, Sialoadhesin family member 2, SAF-2 |
2 | B | N-acetyl-alpha-neuraminic acid-(2-3)-6-O-sulfo-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 900.8 | 1 | In PDB GlyTouCan (G00672PE) | |||
3 | A | 3-aminopropan-1-ol | non-polymer | 75.1 | 1 | Chemie (0D8) |
Sequence modifications
A: 1 - 139 (UniProt: Q9NYZ4)
PDB | External Database | Details |
---|---|---|
Ser 26 | Cys 42 | engineered mutation |
Gly 140 | - | expression tag |
Ser 141 | - | expression tag |
Leu 142 | - | expression tag |
Val 143 | - | expression tag |
Pro 144 | - | expression tag |
Arg 145 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 16665.5 | |
Branched | Number of molecules | 1 |
Total formula weight | 900.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 75.1 | |
All* | Total formula weight | 17641.4 |