2N7B
Solution structure of the human Siglec-8 lectin domain in complex with 6'sulfo sialyl Lewisx
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Sialic acid-binding Ig-like lectin 8 | polymer | 145 | 16665.5 | 1 | UniProt (Q9NYZ4) Pfam (PF07686) | Homo sapiens (human) | Siglec-8, Sialoadhesin family member 2, SAF-2 |
| 2 | B (B) | N-acetyl-alpha-neuraminic acid-(2-3)-6-O-sulfo-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 900.8 | 1 | In PDB GlyTouCan (G00672PE) | |||
| 3 | C (A) | 3-aminopropan-1-ol | non-polymer | 75.1 | 1 | Chemie (0D8) |
Sequence modifications
A: 1 - 139 (UniProt: Q9NYZ4)
| PDB | External Database | Details |
|---|---|---|
| Ser 26 | Cys 42 | engineered mutation |
| Gly 140 | - | expression tag |
| Ser 141 | - | expression tag |
| Leu 142 | - | expression tag |
| Val 143 | - | expression tag |
| Pro 144 | - | expression tag |
| Arg 145 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16665.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 900.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 75.1 | |
| All* | Total formula weight | 17641.4 |
