2N55

Structure of constitutively monomeric CXCL12 in complex with the CXCR4 N-terminus

Summary for 2N55

• Entry DOI: 10.2210/pdb2n55/pdb
• NMR Information: BMRB: 25694
• Descriptor: Stromal cell-derived factor 1, C-X-C chemokine receptor type 4 (2 entities in total)
• Functional Keywords: cxl12, cxcr4, chemokine, gpcr, sdf1, cytokine-signaling protein complex, cytokine/signaling protein
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P48061; Cell membrane; Multi-pass membrane protein: P61073
• Total number of polymer chains: 2
• Total formula weight: 12665.45

Authors

Ziarek, J.J.,Peterson, F.C.,Volkman, B.F. (deposition date: 2015-07-07, release date: 2016-04-27, Last modification date: 2023-06-14)

• Primary citation: Ziarek, J.J.,Kleist, A.B.,London, N.,Raveh, B.,Montpas, N.,Bonneterre, J.,St-Onge, G.,DiCosmo-Ponticello, C.J.,Koplinski, C.A.,Roy, I.,Stephens, B.,Thelen, S.,Veldkamp, C.T.,Coffman, F.D.,Cohen, M.C.,Dwinell, M.B.,Thelen, M.,Peterson, F.C.,Heveker, N.,Volkman, B.F.; Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.; Sci Signal, 10:-, 2017; PubMed: 28325822; DOI: 10.1126/scisignal.aah5756

Experimental method

SOLUTION NMR