2N55
Structure of constitutively monomeric CXCL12 in complex with the CXCR4 N-terminus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Stromal cell-derived factor 1 | polymer | 70 | 8146.7 | 1 | UniProt (P48061) Pfam (PF00048) | Homo sapiens (human) | SDF-1, hSDF-1, C-X-C motif chemokine 12, Intercrine reduced in hepatomas, IRH, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1-beta(3-72), SDF-1-alpha(3-67) |
| 2 | B (B) | C-X-C chemokine receptor type 4 | polymer | 40 | 4518.8 | 1 | UniProt (P61073) Pfam (PF12109) | Homo sapiens (human) | CXC-R4, CXCR-4, FB22, Fusin, HM89, LCR1, Leukocyte-derived seven transmembrane domain receptor, LESTR, Lipopolysaccharide-associated protein 3, LAP-3, LPS-associated protein 3, NPYRL, Stromal cell-derived factor 1 receptor, SDF-1 receptor |
Sequence modifications
A: 1 - 68 (UniProt: P48061)
B: 201 - 238 (UniProt: P61073)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Met 0 | - | expression tag |
| Cys 55 | Leu 76 | engineered mutation |
| Cys 58 | Ile 79 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
| Ser 200 | - | expression tag |
| Ala 228 | Cys 28 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 12665.5 | |
| All* | Total formula weight | 12665.5 |
