2MOE

Solution structure of MBD4 methyl-cytosine binding domain bound to methylated DNA

Summary for 2MOE

• Entry DOI: 10.2210/pdb2moe/pdb
• NMR Information: BMRB: 19939
• Descriptor: Methyl-CpG-binding domain protein 4, DNA (5'-D(*GP*GP*AP*TP*(5CM)P*GP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*CP*(5CM)P*GP*AP*TP*CP*C)-3') (3 entities in total)
• Functional Keywords: protein/dna, methylated dna, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: O95243
• Total number of polymer chains: 3
• Total formula weight: 14207.29

Authors

Williams, D.C.,Walavalkar, N.M. (deposition date: 2014-04-24, release date: 2014-09-10, Last modification date: 2023-06-14)

• Primary citation: Walavalkar, N.M.,Cramer, J.M.,Buchwald, W.A.,Scarsdale, J.N.,Williams, D.C.; Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for mCpG/TpG mismatches.; Nucleic Acids Res., 42:11218-11232, 2015; PubMed: 25183517; DOI: 10.1093/nar/gku782

Experimental method

SOLUTION NMR