2M5K

Atomic-resolution structure of a doublet cross-beta amyloid fibril

Summary for 2M5K

• Entry DOI: 10.2210/pdb2m5k/pdb
• Related: 2M5M 2M5N 3ZPK
• EMDB information: 2323 2324 5590
• NMR Information: BMRB: 19058
• Descriptor: Transthyretin (1 entity in total)
• Functional Keywords: amyloid fibril, cross-beta structure, protein fibril
• Biological source: Rattus norvegicus (rat)
• Total number of polymer chains: 8
• Total formula weight: 9586.93

Authors

Fitzpatrick, A.W.P.,Debelouchina, G.T.,Bayro, M.J.,Clare, D.K.,Caporini, M.A.,Bajaj, V.S.,Jaroniec, C.P.,Wang, L.,Ladizhansky, V.,Muller, S.,MacPhee, C.E.,Waudby, C.A.,Mott, H.R.,de Simone, A.,Knowles, T.P.J.,Saibil, H.R.,Vendruscolo, M.,Orlova, E.V.,Griffin, R.G.,Dobson, C.M. (deposition date: 2013-02-27, release date: 2013-12-04, Last modification date: 2024-05-15)

• Primary citation: Fitzpatrick, A.W.,Debelouchina, G.T.,Bayro, M.J.,Clare, D.K.,Caporini, M.A.,Bajaj, V.S.,Jaroniec, C.P.,Wang, L.,Ladizhansky, V.,Muller, S.A.,MacPhee, C.E.,Waudby, C.A.,Mott, H.R.,De Simone, A.,Knowles, T.P.,Saibil, H.R.,Vendruscolo, M.,Orlova, E.V.,Griffin, R.G.,Dobson, C.M.; Atomic structure and hierarchical assembly of a cross-beta amyloid fibril.; Proc.Natl.Acad.Sci.USA, 110:5468-5473, 2013; PubMed: 23513222; DOI: 10.1073/pnas.1219476110

Experimental method

ELECTRON MICROSCOPY (12.7 Å)
SOLID-STATE NMR (12.7 Å)