2LZG

NMR Structure of Mdm2 (6-125) with Pip-1

Summary for 2LZG

• Entry DOI: 10.2210/pdb2lzg/pdb
• NMR Information: BMRB: 18755
• Descriptor: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid (2 entities in total)
• Functional Keywords: mdm2, oncogene protein-inhibitor complex, protein binding
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 1
• Total formula weight: 14591.52

Authors

Michelsen, K.B.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L. (deposition date: 2012-10-02, release date: 2012-11-07)

• Primary citation: Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L.; Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.; J.Am.Chem.Soc., 134:17059-17067, 2012; PubMed: 22991965; DOI: 10.1021/ja305839b

Experimental method

SOLUTION NMR