2LZG
NMR Structure of Mdm2 (6-125) with Pip-1
Summary for 2LZG
Entry DOI | 10.2210/pdb2lzg/pdb |
NMR Information | BMRB: 18755 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid (2 entities in total) |
Functional Keywords | mdm2, oncogene protein-inhibitor complex, protein binding |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 1 |
Total formula weight | 14591.52 |
Authors | Michelsen, K.B.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L. (deposition date: 2012-10-02, release date: 2012-11-07, Last modification date: 2024-05-01) |
Primary citation | Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L. Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors. J.Am.Chem.Soc., 134:17059-17067, 2012 Cited by PubMed: 22991965DOI: 10.1021/ja305839b PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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