2LSP
solution structures of BRD4 second bromodomain with NF-kB-K310ac peptide
Summary for 2LSP
Entry DOI | 10.2210/pdb2lsp/pdb |
NMR Information | BMRB: 18439 |
Descriptor | NF-kB-K310ac peptide, Bromodomain-containing protein 4 (2 entities in total) |
Functional Keywords | nf-kb, brd4, hiv, bromodomain, kidney disease, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q04206 O60885 |
Total number of polymer chains | 2 |
Total formula weight | 16506.01 |
Authors | Zhang, G.,Liu, R.,Zhong, Y.,Plotnikov, A.N.,Zhang, W.,Rusinova, E.,Gerona-Nevarro, G.,Moshkina, N.,Joshua, J.,Chuang, P.Y.,Ohlmeyer, M.,He, J.,Zhou, M.-M. (deposition date: 2012-05-03, release date: 2012-07-18, Last modification date: 2023-11-15) |
Primary citation | Zhang, G.,Liu, R.,Zhong, Y.,Plotnikov, A.N.,Zhang, W.,Zeng, L.,Rusinova, E.,Gerona-Nevarro, G.,Moshkina, N.,Joshua, J.,Chuang, P.Y.,Ohlmeyer, M.,He, J.C.,Zhou, M.M. Down-regulation of NF-kappa B transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J.Biol.Chem., 287:28840-28851, 2012 Cited by PubMed: 22645123DOI: 10.1074/jbc.M112.359505 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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