2LMS

A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site

2LMS の概要

• エントリーDOI: 10.2210/pdb2lms/pdb
• NMR情報: BMRB: 18135
• 分子名称: Interferon alpha-2, 2-acetamido-2-deoxy-alpha-D-galactopyranose (2 entities in total)
• 機能のキーワード: cytokine, glycoprotein, o-glycosylation, signaling protein, type i interferons, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19616.50

構造登録者

Ghasriani, H.,Belcourt, P.J.F.,Sauve, S.,Hodgson, D.J.,Gingras, G.,Brochu, D.,Gilbert, M.,Aubin, Y. (登録日: 2011-12-12, 公開日: 2012-12-05, 最終更新日: 2023-06-14)

• 主引用文献: Ghasriani, H.,Belcourt, P.J.,Sauve, S.,Hodgson, D.J.,Brochu, D.,Gilbert, M.,Aubin, Y.; A single N-acetylgalactosamine residue at threonine 106 modifies the dynamics and structure of interferon alpha2a around the glycosylation site.; J.Biol.Chem., 288:247-254, 2013; PubMed: 23184955; DOI: 10.1074/jbc.M112.413252

実験手法

SOLUTION NMR