2L27

NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist

Summary for 2L27

• Entry DOI: 10.2210/pdb2l27/pdb
• Related: 2JNC 2JND
• Descriptor: Corticotropin-releasing factor receptor 1, peptide agonist (2 entities in total)
• Functional Keywords: crf, ecd1, agonist, family b1, alpha helical crf, membrane protein, peptide binding protein
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Multi-pass membrane protein: P34998
• Total number of polymer chains: 2
• Total formula weight: 13560.15

Authors

Grace, C.R.R.,Perrin, M.H.,Gulyas, J.R.R.,Rivier, J.E.,Vale, W.W.,Riek, R.R. (deposition date: 2010-08-12, release date: 2010-09-01, Last modification date: 2017-03-01)

• Primary citation: Grace, C.R.,Perrin, M.H.,Gulyas, J.,Rivier, J.E.,Vale, W.W.,Riek, R.; NMR structure of the first extracellular domain of corticotropin-releasing factor receptor 1 (ECD1-CRF-R1) complexed with a high affinity agonist.; J.Biol.Chem., 285:38580-38589, 2010; PubMed: 20843795; DOI: 10.1074/jbc.M110.121897

Experimental method

SOLUTION NMR