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2L27

NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist

Functional Information from GO Data
ChainGOidnamespacecontents
A0004930molecular_functionG protein-coupled receptor activity
A0007186biological_processG protein-coupled receptor signaling pathway
A0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00511
Number of Residues16
DetailsCRF Corticotropin-releasing factor family signature. PpISLdlTFnLLRevL
ChainResidueDetails
BPRO304-LEU319

site_idPS00649
Number of Residues26
DetailsG_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnasVDligtCWprSpagqlvvrpCP
ChainResidueDetails
ACYS144-PRO169

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsRegion: {"description":"Important for peptide agonist binding"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues5
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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