2KWG

Solution structure of a fully modified 2'-F/2'-OMe siRNA construct

Summary for 2KWG

Entry DOI	10.2210/pdb2kwg/pdb
NMR Information	BMRB: 16852
Descriptor	5'-R((GF2)P(OMG)P(GF2)P(OMU)P(AF2)P(A2M)P(AF2)P(OMU)P(AF2)P(OMC)P(AF2)P(OMU)P(UFT)P(OMC)P(UFT)P(OMU)P(CFZ)P(A2M)P(UFT)P(OMU)P(UFT))-3', 5'-R(P(A2M)P(UFT)P(OMG)P(AF2)P(A2M)P(GF2)P(A2M)P(AF2)P(OMU)P(GF2)P(OMU)P(AF2)P(OMU)P(UFT)P(OMU)P(AF2)P(OMC)P(CFZ)P(OMC)P(UFT)P(OMU))-3' (2 entities in total)
Functional Keywords	sirna, 2'-fluoro, 2'-o-methyl, rna
Total number of polymer chains	2
Total formula weight	13633.28
Authors	Podbevsek, P.,Bhat, B.,Plavec, J. (deposition date: 2010-04-09, release date: 2010-07-21, Last modification date: 2011-07-13)
Primary citation	Podbevsek, P.,Allerson, C.R.,Bhat, B.,Plavec, J. Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct. Nucleic Acids Res., 38:7298-7307, 2010 Cited by PubMed: 20624819 DOI: 10.1093/nar/gkq621 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation