2KNI
High-resolution solution structure of the ASIC1a blocker PcTX1
Summary for 2KNI
| Entry DOI | 10.2210/pdb2kni/pdb |
| Related | 1LMM |
| NMR Information | BMRB: 16468 |
| Descriptor | Psalmotoxin-1 (1 entity in total) |
| Functional Keywords | psalmotoxin 1, pi-theraphotoxin-pc1a, cystine knot, spider toxin, peptide toxin, disulfide bond, ionic channel inhibitor, knottin, neurotoxin, secreted, asic1a inhibitor, acid sensing ion channel 1a inhibitor, toxin |
| Biological source | Psalmopoeus cambridgei (Trinidad chevron tarantula) |
| Total number of polymer chains | 1 |
| Total formula weight | 4792.59 |
| Authors | King, G.F.,Mobli, M.,Saez, N.J. (deposition date: 2009-08-25, release date: 2010-09-01, Last modification date: 2023-06-14) |
| Primary citation | Saez, N.J.,Mobli, M.,Bieri, M.,Chassagnon, I.R.,Malde, A.K.,Gamsjaeger, R.,Mark, A.E.,Gooley, P.R.,Rash, L.D.,King, G.F. A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a. Mol.Pharmacol., 80:796-808, 2011 Cited by PubMed: 21825095DOI: 10.1124/mol.111.072207 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
Download full validation report
