2KGK

Solution structure of Bacillus anthracis dihydrofolate reductase

Summary for 2KGK

• Entry DOI: 10.2210/pdb2kgk/pdb
• NMR Information: BMRB: 16822
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (3 entities in total)
• Functional Keywords: dhfr, oxidoreductase
• Biological source: Bacillus anthracis (anthrax,anthrax bacterium)
• Total number of polymer chains: 1
• Total formula weight: 21552.07

Authors

Deshmukh, L.,Vinogradova, O.,Beierlein, J.M.,Frey, K.M.,Anderson, A.C. (deposition date: 2009-03-12, release date: 2009-05-12, Last modification date: 2024-05-22)

• Primary citation: Beierlein, J.M.,Deshmukh, L.,Frey, K.M.,Vinogradova, O.,Anderson, A.C.; The solution structure of Bacillus anthracis dihydrofolate reductase yields insight into the analysis of structure-activity relationships for novel inhibitors.; Biochemistry, 48:4100-4108, 2009; PubMed: 19323450; DOI: 10.1021/bi802319w

Experimental method

SOLUTION NMR