Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NAP A 173 |
| Chain | Residue |
| A | ALA8 |
| A | ARG65 |
| A | SER79 |
| A | PHE96 |
| A | GLY97 |
| A | GLY98 |
| A | ALA99 |
| A | GLN100 |
| A | ILE101 |
| A | THR125 |
| A | ILE15 |
| A | ASN19 |
| A | ASN20 |
| A | LEU21 |
| A | ARG45 |
| A | LYS46 |
| A | ASN47 |
| A | THR64 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE N22 A 174 |
| Chain | Residue |
| A | LEU21 |
| A | PRO22 |
| A | TRP23 |
| A | ARG24 |
| A | VAL32 |
| A | ILE51 |
| A | ARG53 |
| A | PHE96 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnnLPWrlps.ElqyVkktT |
| Chain | Residue | Details |
| A | VAL14-THR36 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | GLU28 | |
| A | LEU21 | |
2KGK
