2KFX

Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7

Summary for 2KFX

Entry DOI	10.2210/pdb2kfx/pdb
NMR Information	BMRB: 16190
Descriptor	Troponin C, slow skeletal and cardiac muscles, CALCIUM ION, N-(6-AMINOHEXYL)-5-CHLORO-1-NAPHTHALENESULFONAMIDE (3 entities in total)
Functional Keywords	calcium regulation, striated muscle, cardiac, troponin, w7, cardiotonic drugs, acetylation, calcium, cardiomyopathy, disease mutation, muscle protein, polymorphism, metal binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	10419.12
Authors	Hoffman, R.M.B.,Sykes, B.D. (deposition date: 2009-02-28, release date: 2009-06-09, Last modification date: 2021-10-20)
Primary citation	Hoffman, R.M.,Sykes, B.D. Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C. Biochemistry, 48:5541-5552, 2009 Cited by PubMed: 19419198 DOI: 10.1021/bi9001826 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation