2JVE
Solution structure of the extracellular domain of Prod1, a protein implicated in proximodistal identity during amphibian limb regeneration
Summary for 2JVE
| Entry DOI | 10.2210/pdb2jve/pdb |
| NMR Information | BMRB: 15477 |
| Descriptor | Prod 1 (1 entity in total) |
| Functional Keywords | ly-6, three-finger snake toxin, upar, cd59, limb regeneration, toxin |
| Biological source | Notophthalmus viridescens (red-spotted newt) |
| Total number of polymer chains | 1 |
| Total formula weight | 10223.50 |
| Authors | Garza-Garcia, A.,Harris, R.,Esposito, D.,Driscoll, P.C. (deposition date: 2007-09-19, release date: 2008-09-30, Last modification date: 2024-11-06) |
| Primary citation | Garza-Garcia, A.,Harris, R.,Esposito, D.,Gates, P.B.,Driscoll, P.C. Solution structure and phylogenetics of Prod1, a member of the three-finger protein superfamily implicated in salamander limb regeneration. Plos One, 4:e7123-e7123, 2009 Cited by PubMed Abstract: Following the amputation of a limb, newts and salamanders have the capability to regenerate the lost tissues via a complex process that takes place at the site of injury. Initially these cells undergo dedifferentiation to a state competent to regenerate the missing limb structures. Crucially, dedifferentiated cells have memory of their level of origin along the proximodistal (PD) axis of the limb, a property known as positional identity. Notophthalmus viridescens Prod1 is a cell-surface molecule of the three-finger protein (TFP) superfamily involved in the specification of newt limb PD identity. The TFP superfamily is a highly diverse group of metazoan proteins that includes snake venom toxins, mammalian transmembrane receptors and miscellaneous signaling molecules. PubMed: 19771161DOI: 10.1371/journal.pone.0007123 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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