2JM6

Solution structure of MCL-1 complexed with NOXAB

Summary for 2JM6

• Entry DOI: 10.2210/pdb2jm6/pdb
• Related: 1WSX
• Descriptor: Noxa, Myeloid cell leukemia-1 protein Mcl-1 homolog (2 entities in total)
• Functional Keywords: apoptosis, mcl-1, bcl-2, helical bundle, bh3-only
• Biological source: Mus musculus (house mouse); More
• Cellular location: Mitochondrion: Q9JM54; Membrane; Single-pass membrane protein (By similarity): P97287
• Total number of polymer chains: 2
• Total formula weight: 21405.38

Authors

Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.S.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M. (deposition date: 2006-10-17, release date: 2007-03-20, Last modification date: 2023-12-20)

• Primary citation: Czabotar, P.E.,Lee, E.F.,van Delft, M.F.,Day, C.L.,Smith, B.J.,Huang, D.C.S.,Fairlie, W.D.,Hinds, M.G.,Colman, P.M.; Structural insights into the degradation of Mcl-1 induced by BH3 domains; Proc.Natl.Acad.Sci.Usa, 104:6217-6222, 2007; PubMed: 17389404; DOI: 10.1073/pnas.0701297104

Experimental method

SOLUTION NMR