2JLR

Dengue virus 4 NS3 helicase in complex with AMPPNP

2JLR の概要

• エントリーDOI: 10.2210/pdb2jlr/pdb
• 関連するPDBエントリー: 2JLQ 2JLS 2JLU 2JLV 2JLW 2JLX 2JLY 2JLZ
• 分子名称: SERINE PROTEASE SUBUNIT NS3, MANGANESE (II) ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (4 entities in total)
• 機能のキーワード: ribonucleoprotein, nucleotide-binding, helicase, protease, hydrolase, atp analog, transferase, viral nucleoprotein, endoplasmic reticulum, cleavage on pair of basic residues, multifunctional enzyme, transcription regulation, nucleotidyltransferase, ns3 helicase structure, virion, atpase, nucleus, membrane, secreted, atp-binding, rna-binding, flaviviruses, glycoprotein, rna-directed rna polymerase, rna replication, serine protease, envelope protein, dengue virus, metal-binding, transmembrane, transcription, phosphoprotein, capsid protein
• 由来する生物種: DENGUE VIRUS 4
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q2YHF0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51914.61

構造登録者

Luo, D.H.,Xu, T.,Watson, R.P.,Becker, D.S.,Sampath, A.,Jahnke, W.,Yeong, S.S.,Wang, C.H.,Lim, S.P.,Vasudevan, S.G.,Lescar, J. (登録日: 2008-09-15, 公開日: 2008-11-25, 最終更新日: 2023-12-13)

• 主引用文献: Luo, D.,Xu, T.,Watson, R.P.,Scherer-Becker, D.,Sampath, A.,Jahnke, W.,Yeong, S.S.,Wang, C.H.,Lim, S.P.,Strongin, A.,Vasudevan, S.G.,Lescar, J.; Insights Into RNA Unwinding and ATP Hydrolysis by the Flavivirus Ns3 Protein.; Embo J., 27:3209-, 2008; PubMed: 19008861; DOI: 10.1038/EMBOJ.2008.232

実験手法

X-RAY DIFFRACTION (2 Å)