2JGM
Crystal structure of mouse acetylcholinesterase inhibited by aged diisopropyl fluorophosphate (DFP)
Summary for 2JGM
Entry DOI | 10.2210/pdb2jgm/pdb |
Related | 1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 2JEY 2JEZ 2JF0 2JGE 2JGF 2JGG 2JGH 2JGI 2JGJ 2JGK 2JGL |
Descriptor | ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total) |
Functional Keywords | hydrolase, neurotransmitter degradation, dfp, aging, synapse, membrane, glycoprotein, serine esterase, acetylcholinesterase, alternative splicing, diisopropyl fluorophosphate |
Biological source | MUS MUSCULUS (MOUSE) |
Total number of polymer chains | 2 |
Total formula weight | 120933.30 |
Authors | Hornberg, A.,Tunemalm, A.-K.,Ekstrom, F. (deposition date: 2007-02-13, release date: 2007-04-17, Last modification date: 2023-12-13) |
Primary citation | Hornberg, A.,Tunemalm, A.-K.,Ekstrom, F. Crystal Structures of Acetylcholinesterase in Complex with Organophosphorus Compounds Suggest that the Acyl Pocket Modulates the Aging Reaction by Precluding the Formation of the Trigonal Bipyramidal Transition State. Biochemistry, 46:4815-, 2007 Cited by PubMed: 17402711DOI: 10.1021/BI0621361 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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