2JGJ

Crystal structure of mouse acetylcholinesterase inhibited by aged methamidophos

2JGJ の概要

• エントリーDOI: 10.2210/pdb2jgj/pdb
• 関連するPDBエントリー: 1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 2JEY 2JEZ 2JF0 2JGE 2JGF 2JGG 2JGH 2JGI 2JGK 2JGL 2JGM
• 分子名称: ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-(2-ETHOXYETHOXY)ETHANOL, ... (5 entities in total)
• 機能のキーワード: aging, synapse, membrane, hydrolase, methamidophos, serine esterase, neurotransmitter degradation
• 由来する生物種: MUS MUSCULUS (MOUSE)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121484.89

構造登録者

Hornberg, A.,Tunemalm, A.-K.,Ekstrom, F. (登録日: 2007-02-13, 公開日: 2007-04-17, 最終更新日: 2023-12-13)

• 主引用文献: Hornberg, A.,Tunemalm, A.-K.,Ekstrom, F.; Crystal Structures of Acetylcholinesterase in Complex with Organophosphorus Compounds Suggest that the Acyl Pocket Modulates the Aging Reaction by Precluding the Formation of the Trigonal Bipyramidal Transition State.; Biochemistry, 46:4815-, 2007; PubMed: 17402711; DOI: 10.1021/BI0621361

実験手法

X-RAY DIFFRACTION (2.5 Å)