2JEZ

Mus musculus acetylcholinesterase in complex with tabun and HLo-7

2JEZ の概要

• エントリーDOI: 10.2210/pdb2jez/pdb
• 関連するPDBエントリー: 1C2B 1C2O 1J06 1J07 1KU6 1MAA 1MAH 1N5M 1N5R 1Q83 1Q84 2C0P 2C0Q 2H9Y 2HA0 2HA2 2HA3 2HA4 2HA5 2HA6 2HA7 2JEY 2JF0
• 分子名称: ACETYLCHOLINESTERASE, 1-[({2,4-BIS[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]-4-CARBAMOYLPYRIDINIUM, HEXAETHYLENE GLYCOL, ... (4 entities in total)
• 機能のキーワード: acetylcholinesterase, alternative splicing, neurotransmitter degradation, hydrolase, mus musculus, glycoprotein, serine esterase, oxime, mouse, hlo-7, tabun, synapse, membrane
• 由来する生物種: MUS MUSCULUS (MOUSE)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 121683.16

構造登録者

Ekstrom, F.,Astot, C.,Pang, Y.P. (登録日: 2007-01-25, 公開日: 2007-07-03, 最終更新日: 2023-12-13)

• 主引用文献: Ekstrom, F.J.,Astot, C.,Pang, Y.; Novel Nerve-Agent Antidote Design Based on Crystallographic and Mass Spectrometric Analyses of Tabun-Conjugated Acetylcholinesterase in Complex with Antidotes.; Clin.Pharmacol.Ther., 82:282-, 2007; PubMed: 17443135; DOI: 10.1038/SJ.CLPT.6100151

実験手法

X-RAY DIFFRACTION (2.6 Å)