2JCH

Structural and mechanistic basis of penicillin binding protein inhibition by lactivicins

Summary for 2JCH

• Entry DOI: 10.2210/pdb2jch/pdb
• Related: 2BG1 2BG3 2BG4 2FFF 2JCI
• Descriptor: PENICILLIN-BINDING PROTEIN 1B, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: peptidoglycan synthesis multifunctional enzyme, cell wall, peptidoglycan, gamma lactam antibiotics, binding protein, drug-binding protein
• Biological source: STREPTOCOCCUS PNEUMONIAE
• Total number of polymer chains: 1
• Total formula weight: 79004.23

Authors

Macheboeuf, P.,Fisher, D.S.,Brown, T.J.,Zervosen, A.,Luxen, A.,Joris, B.,Dessen, A.,Schofield, C.J. (deposition date: 2006-12-23, release date: 2007-08-14, Last modification date: 2023-12-13)

• Primary citation: Macheboeuf, P.,Fisher, D.S.,Brown, T.J.,Zervosen, A.,Luxen, A.,Joris, B.,Dessen, A.,Schofield, C.J.; Structural and Mechanistic Basis of Penicillin-Binding Protein Inhibition by Lactivicins; Nat.Chem.Biol., 3:565-, 2007; PubMed: 17676039; DOI: 10.1038/NCHEMBIO.2007.21

Experimental method

X-RAY DIFFRACTION (2.4 Å)