2JCH
Structural and mechanistic basis of penicillin binding protein inhibition by lactivicins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PENICILLIN-BINDING PROTEIN 1B | polymer | 720 | 78428.3 | 1 | UniProt (O70038) Pfam (PF00912) Pfam (PF00905) | STREPTOCOCCUS PNEUMONIAE | |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | (2E)-2-({(2S)-2-CARBOXY-2-[(PHENOXYACETYL)AMINO]ETHOXY}IMINO)PENTANEDIOIC ACID | non-polymer | 382.3 | 1 | Chemie (PL7) | |||
| 6 | F (A) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A: 72 - 791 (UniProt: O70038)
| PDB | External Database | Details |
|---|---|---|
| Ser 73 | Ala 73 | engineered mutation |
| Met 123 | Leu 123 | engineered mutation |
| Asn 158 | Lys 158 | engineered mutation |
| Pro 162 | Arg 162 | engineered mutation |
| Gln 336 | Arg 336 | engineered mutation |
| Gln 686 | Arg 686 | engineered mutation |
| Gln 687 | Arg 687 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 78428.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 575.9 | |
| All* | Total formula weight | 79004.2 |
