2JBU

Crystal structure of human insulin degrading enzyme complexed with co- purified peptides.

2JBU の概要

• エントリーDOI: 10.2210/pdb2jbu/pdb
• 分子名称: INSULIN-DEGRADING ENZYME, CO-PURIFIED PEPTIDE, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total)
• 機能のキーワード: metal-binding, metalloprotease, zinc, protease, hydrolase, enzyme assay, insulin degrading enzyme
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 231348.39

構造登録者

Im, H.,Shen, Y.,Tang, W.J. (登録日: 2006-12-11, 公開日: 2007-07-03, 最終更新日: 2023-12-13)

• 主引用文献: Im, H.,Manolopoulou, M.,Malito, E.,Shen, Y.,Zhao, J.,Neant-Fery, M.,Sun, C.-Y.,Meredith, S.C.,Sisodia, S.S.,Leissring, M.A.,Tang, W.J.; Structure of Substrate-Free Human Insulin Degrading Enzyme (Ide) and Biophysical Analysis of ATP-Induced Conformational Switch of Ide; J.Biol.Chem., 282:25453-, 2007; PubMed: 17613531; DOI: 10.1074/JBC.M701590200

実験手法

X-RAY DIFFRACTION (3 Å)