2JBJ
membrane-bound glutamate carboxypeptidase II (GCPII) in complex with 2-PMPA (2-phosphonoMethyl-pentanedioic acid)
Summary for 2JBJ
Entry DOI | 10.2210/pdb2jbj/pdb |
Related | 1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBK |
Descriptor | GLUTAMATE CARBOXYPEPTIDASE 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | multifunctional enzyme, neurodegenerative disease, glycoprotein, metal-binding, signal-anchor, hydrolase, naaladase, dipeptidase, polymorphism, zinc, psma, antigen, membrane, protease, peptidase, transmembrane, metal- binding, metalloprotease, prostate cancer, carboxypeptidase, alternative splicing |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 82732.73 |
Authors | Mesters, J.R.,Henning, K.,Hilgenfeld, R. (deposition date: 2006-12-07, release date: 2006-12-18, Last modification date: 2020-07-29) |
Primary citation | Mesters, J.R.,Henning, K.,Hilgenfeld, R. Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa. Acta Crystallogr.,Sect.D, 63:508-, 2007 Cited by PubMed: 17372356DOI: 10.1107/S090744490700902X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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