2C6G

Membrane-bound glutamate carboxypeptidase II (GCPII) with bound glutamate

Summary for 2C6G

• Entry DOI: 10.2210/pdb2c6g/pdb
• Related: 1Z8L 2C6C 2C6P
• Descriptor: GLUTAMATE CARBOXYPEPTIDASE II, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: naaladase, neurodegenerative disease, peptidase, prostate cancer, psma, glycoprotein, hydrolase, alternative splicing, antigen, carboxypeptidase, dipeptidase, metal-binding, metalloprotease, multifunctional enzyme, polymorphism, signal-anchor, transmembrane, zinc
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 82229.34

Authors

Mesters, J.R.,Barinka, C.,Li, W.,Tsukamoto, T.,Majer, P.,Slusher, B.S.,Konvalinka, J.,Hilgenfeld, R. (deposition date: 2005-11-09, release date: 2006-02-15, Last modification date: 2020-07-29)

• Primary citation: Mesters, J.R.,Barinka, C.,Li, W.,Tsukamoto, T.,Majer, P.,Slusher, B.S.,Konvalinka, J.,Hilgenfeld, R.; Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.; EMBO J., 25:1375-1384, 2006; PubMed: 16467855; DOI: 10.1038/sj.emboj.7600969

Experimental method

X-RAY DIFFRACTION (2.2 Å)