2JBJ

membrane-bound glutamate carboxypeptidase II (GCPII) in complex with 2-PMPA (2-phosphonoMethyl-pentanedioic acid)

2JBJ の概要

• エントリーDOI: 10.2210/pdb2jbj/pdb
• 関連するPDBエントリー: 1Z8L 2C6C 2C6G 2C6P 2CIJ 2JBK
• 分子名称: GLUTAMATE CARBOXYPEPTIDASE 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: multifunctional enzyme, neurodegenerative disease, glycoprotein, metal-binding, signal-anchor, hydrolase, naaladase, dipeptidase, polymorphism, zinc, psma, antigen, membrane, protease, peptidase, transmembrane, metal- binding, metalloprotease, prostate cancer, carboxypeptidase, alternative splicing
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 82732.73

構造登録者

Mesters, J.R.,Henning, K.,Hilgenfeld, R. (登録日: 2006-12-07, 公開日: 2006-12-18, 最終更新日: 2020-07-29)

• 主引用文献: Mesters, J.R.,Henning, K.,Hilgenfeld, R.; Human Glutamate Carboxypeptidase II Inhibition: Structures of Gcpii in Complex with Two Potent Inhibitors, Quisqualate and 2-Pmpa.; Acta Crystallogr.,Sect.D, 63:508-, 2007; PubMed: 17372356; DOI: 10.1107/S090744490700902X

実験手法

X-RAY DIFFRACTION (2.19 Å)