2JAP

Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the beta-Lactamase Inhibitor Clavulanic acid

Summary for 2JAP

• Entry DOI: 10.2210/pdb2jap/pdb
• Related: 2JAH
• Descriptor: CLAVALDEHYDE DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, ... (4 entities in total)
• Functional Keywords: short-chain dehydrogenase/reductase, oxidoreductase, antibiotic biosynthesis, beta-lactamase inhibitor
• Biological source: STREPTOMYCES CLAVULIGERUS
• Total number of polymer chains: 4
• Total formula weight: 109206.70

Authors

MacKenzie, A.K.,Kershaw, N.J.,Hernandez, H.,Robinson, C.V.,Schofield, C.J.,Andersson, I. (deposition date: 2006-11-29, release date: 2007-02-20, Last modification date: 2011-07-13)

• Primary citation: Mackenzie, A.K.,Kershaw, N.J.,Hernandez, H.,Robinson, C.V.,Schofield, C.J.,Andersson, I.; Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the Beta-Lactamase Inhibitor Clavulanic Acid; Biochemistry, 46:1523-, 2007; PubMed: 17279617; DOI: 10.1021/BI061978X

Experimental method

X-RAY DIFFRACTION (2.1 Å)