2JAP
Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the beta-Lactamase Inhibitor Clavulanic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP A1248 |
| Chain | Residue |
| A | GLY14 |
| A | ASP64 |
| A | VAL65 |
| A | ASN91 |
| A | ALA92 |
| A | GLY93 |
| A | THR114 |
| A | MET140 |
| A | SER141 |
| A | SER142 |
| A | TYR155 |
| A | SER16 |
| A | LYS159 |
| A | PRO185 |
| A | GLY186 |
| A | THR187 |
| A | THR188 |
| A | THR190 |
| A | GLU191 |
| A | LEU192 |
| A | J011249 |
| A | HOH2015 |
| A | SER17 |
| A | HOH2062 |
| A | HOH2063 |
| A | HOH2064 |
| A | HOH2065 |
| A | HOH2066 |
| A | HOH2067 |
| A | GLY18 |
| A | ILE19 |
| A | ALA38 |
| A | ARG39 |
| A | ARG40 |
| A | LEU63 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE J01 A1249 |
| Chain | Residue |
| A | MET95 |
| A | SER142 |
| A | ILE143 |
| A | ALA144 |
| A | ALA152 |
| A | TYR155 |
| A | GLN156 |
| A | THR187 |
| A | TYR205 |
| A | ARG208 |
| A | NDP1248 |
| A | HOH2033 |
| A | HOH2058 |
| A | HOH2068 |
| site_id | AC3 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP B1248 |
| Chain | Residue |
| A | GLN69 |
| B | GLY14 |
| B | SER16 |
| B | SER17 |
| B | GLY18 |
| B | ILE19 |
| B | ALA38 |
| B | ARG39 |
| B | ARG40 |
| B | LEU63 |
| B | ASP64 |
| B | VAL65 |
| B | ASN91 |
| B | ALA92 |
| B | GLY93 |
| B | THR114 |
| B | MET140 |
| B | SER141 |
| B | SER142 |
| B | TYR155 |
| B | LYS159 |
| B | PRO185 |
| B | GLY186 |
| B | THR187 |
| B | THR188 |
| B | THR190 |
| B | GLU191 |
| B | LEU192 |
| B | J011249 |
| B | HOH2001 |
| B | HOH2003 |
| B | HOH2007 |
| B | HOH2054 |
| B | HOH2055 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE J01 B1249 |
| Chain | Residue |
| B | MET95 |
| B | LEU97 |
| B | SER142 |
| B | ILE143 |
| B | ALA144 |
| B | ALA152 |
| B | TYR155 |
| B | GLN156 |
| B | THR187 |
| B | TYR205 |
| B | ARG208 |
| B | NDP1248 |
| B | HOH2051 |
| site_id | AC5 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP C1248 |
| Chain | Residue |
| C | GLY18 |
| C | ILE19 |
| C | ALA38 |
| C | ARG39 |
| C | ARG40 |
| C | LEU63 |
| C | ASP64 |
| C | VAL65 |
| C | ASN91 |
| C | ALA92 |
| C | GLY93 |
| C | THR114 |
| C | MET140 |
| C | SER141 |
| C | SER142 |
| C | TYR155 |
| C | LYS159 |
| C | PRO185 |
| C | GLY186 |
| C | THR187 |
| C | THR188 |
| C | THR190 |
| C | GLU191 |
| C | LEU192 |
| C | J011249 |
| C | HOH2003 |
| C | HOH2051 |
| C | HOH2070 |
| C | HOH2071 |
| C | HOH2072 |
| C | GLY14 |
| C | SER16 |
| C | SER17 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE J01 C1249 |
| Chain | Residue |
| C | MET95 |
| C | SER142 |
| C | ALA144 |
| C | ALA152 |
| C | TYR155 |
| C | GLN156 |
| C | THR187 |
| C | TYR205 |
| C | ARG208 |
| C | NDP1248 |
| C | HOH2067 |
| C | HOH2073 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NDP D1248 |
| Chain | Residue |
| D | GLY14 |
| D | SER16 |
| D | SER17 |
| D | GLY18 |
| D | ILE19 |
| D | ALA38 |
| D | ARG39 |
| D | ARG40 |
| D | LEU63 |
| D | ASP64 |
| D | VAL65 |
| D | ASN91 |
| D | ALA92 |
| D | GLY93 |
| D | THR114 |
| D | MET140 |
| D | SER141 |
| D | SER142 |
| D | TYR155 |
| D | LYS159 |
| D | PRO185 |
| D | GLY186 |
| D | THR187 |
| D | THR188 |
| D | THR190 |
| D | GLU191 |
| D | LEU192 |
| D | J011249 |
| D | HOH2054 |
| D | HOH2055 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE J01 D1249 |
| Chain | Residue |
| D | MET95 |
| D | SER142 |
| D | ALA144 |
| D | ALA152 |
| D | TYR155 |
| D | GLN156 |
| D | THR187 |
| D | TYR205 |
| D | ARG208 |
| D | NDP1248 |
| D | HOH2052 |
| D | HOH2056 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | SER142 | |
| A | TYR155 | |
| A | LYS159 |
| site_id | CSA10 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | ALA152 | |
| B | LYS159 |
| site_id | CSA11 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | ALA152 | |
| C | LYS159 |
| site_id | CSA12 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | ALA152 | |
| D | LYS159 |
| site_id | CSA13 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | TYR155 | |
| A | LYS159 |
| site_id | CSA14 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | TYR155 | |
| B | LYS159 |
| site_id | CSA15 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | TYR155 | |
| C | LYS159 |
| site_id | CSA16 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | TYR155 | |
| D | LYS159 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | SER142 | |
| B | TYR155 | |
| B | LYS159 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | SER142 | |
| C | TYR155 | |
| C | LYS159 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | SER142 | |
| D | TYR155 | |
| D | LYS159 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | TYR155 | |
| A | SER142 | |
| A | ASN115 | |
| A | LYS159 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| B | TYR155 | |
| B | SER142 | |
| B | ASN115 | |
| B | LYS159 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| C | TYR155 | |
| C | SER142 | |
| C | ASN115 | |
| C | LYS159 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| D | TYR155 | |
| D | SER142 | |
| D | ASN115 | |
| D | LYS159 |
| site_id | CSA9 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1eq2 |
| Chain | Residue | Details |
| A | ALA152 | |
| A | LYS159 |
