2J87

Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design

2J87 の概要

• エントリーDOI: 10.2210/pdb2j87/pdb
• 分子名称: THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ZINC ION, ... (4 entities in total)
• 機能のキーワード: type 2 thymidine kinase, dna synthesis, nucleotide-binding, dttp, kinase, transferase, atp-binding, vaccinia virus thymidine kinase
• 由来する生物種: VACCINIA VIRUS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 82552.37

構造登録者

El Omari, K.,Solaroli, N.,Karlsson, A.,Balzarini, J.,Stammers, D.K. (登録日: 2006-10-23, 公開日: 2006-11-13, 最終更新日: 2024-11-06)

主引用文献

El Omari, K.,Solaroli, N.,Karlsson, A.,Balzarini, J.,Stammers, D.K.
Structure of Vaccinia Virus Thymidine Kinase in Complex with Dttp: Insights for Drug Design.
Bmc Struct.Biol., 6:22-, 2006

PubMed Abstract: Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of nucleoside analogues by virus-encoded thymidine (dThd) kinases (TK) represents one of the most successful strategies for antiviral chemotherapy as demonstrated for anti-herpes drugs. Vaccinia virus TK is a close orthologue of variola TK but also shares a relatively high sequence identity to human type 2 TK (hTK), thus achieving drug selectivity relative to the host enzyme is challenging.

PubMed: 17062140
DOI: 10.1186/1472-6807-6-22

実験手法

X-RAY DIFFRACTION (3.1 Å)