2J2S

Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase

2J2S の概要

• エントリーDOI: 10.2210/pdb2j2s/pdb
• 関連するPDBエントリー: 2AGH
• 分子名称: ZINC FINGER PROTEIN HRX, ZINC ION (2 entities in total)
• 機能のキーワード: transcription regulation, chromosomal rearrangement, zinc-finger, dna-binding, bromodomain, polymorphism, mixed lineage leukaemia, zinc binding, transcription, metal-binding, zinc, cxxc, mbd1, hox genes, chromatin, methylation, proto-oncogene, nuclear protein, phosphorylation, cpg dinucleotide, alternative splicing
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus . MLL cleavage product N320: Nucleus. MLL cleavage product C180: Nucleus: Q03164
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 8197.48

構造登録者

Allen, M.D.,Grummitt, C.G.,Hilcenko, C.,Young-Min, S.,Tonkin, L.M.,Johnson, C.M.,Bycroft, M.,Warren, A.J. (登録日: 2006-08-17, 公開日: 2006-08-21, 最終更新日: 2024-05-15)

• 主引用文献: Allen, M.D.,Grummitt, C.G.,Hilcenko, C.,Min, S.Y.,Tonkin, L.M.,Johnson, C.M.,Freund, S.M.,Bycroft, M.,Warren, A.J.; Solution Structure of the Nonmethyl-Cpg-Binding Cxxc Domain of the Leukaemia-Associated Mll Histone Methyltransferase; Embo J., 25:4503-, 2006; PubMed: 16990798; DOI: 10.1038/SJ.EMBOJ.7601340

実験手法

SOLUTION NMR