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2IRZ

Crystal structure of human Beta-secretase complexed with inhibitor

Summary for 2IRZ
Entry DOI10.2210/pdb2irz/pdb
Related1TQF 2B8V 2IS0
DescriptorBeta-secretase 1, 3-{5-[(1R)-1-AMINO-1-METHYL-2-PHENYLETHYL]-1,3,4-OXADIAZOL-2-YL}-N-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZAMIDE (3 entities in total)
Functional Keywordsaspartyl protease, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein: P56817
Total number of polymer chains1
Total formula weight45674.38
Authors
Munshi, S. (deposition date: 2006-10-16, release date: 2006-11-14, Last modification date: 2023-08-30)
Primary citationRajapakse, H.A.,Nantermet, P.G.,Selnick, H.G.,Munshi, S.,McGaughey, G.B.,Lindsley, S.R.,Young, M.B.,Lai, M.T.,Espeseth, A.S.,Shi, X.P.,Colussi, D.,Pietrak, B.,Crouthamel, M.C.,Tugusheva, K.,Huang, Q.,Xu, M.,Simon, A.J.,Kuo, L.,Hazuda, D.J.,Graham, S.,Vacca, J.P.
Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
J.Med.Chem., 49:7270-7273, 2006
Cited by
PubMed: 17149856
DOI: 10.1021/jm061046r
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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