2IS0
Crystal structure of human Beta-secretase complexed with inhibitor
Summary for 2IS0
Entry DOI | 10.2210/pdb2is0/pdb |
Related | 1TQF 2B8V 2IRZ |
Descriptor | Beta-secretase 1, (2S)-2-AMINO-2-BENZYL-3-HYDROXYPROPYL 3-({[(1R)-1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)-5-[METHYL(METHYLSULFONYL)AMINO]BENZOATE (3 entities in total) |
Functional Keywords | aspartyl protease, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 1 |
Total formula weight | 45680.38 |
Authors | Munshi, S. (deposition date: 2006-10-16, release date: 2006-11-14, Last modification date: 2023-08-30) |
Primary citation | Rajapakse, H.A.,Nantermet, P.G.,Selnick, H.G.,Munshi, S.,McGaughey, G.B.,Lindsley, S.R.,Young, M.B.,Lai, M.T.,Espeseth, A.S.,Shi, X.P.,Colussi, D.,Pietrak, B.,Crouthamel, M.C.,Tugusheva, K.,Huang, Q.,Xu, M.,Simon, A.J.,Kuo, L.,Hazuda, D.J.,Graham, S.,Vacca, J.P. Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1). J.Med.Chem., 49:7270-7273, 2006 Cited by PubMed: 17149856DOI: 10.1021/jm061046r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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