2IPH

X-ray Structure at 1.75 A Resolution of a Norovirus Protease Linked to an Active Site Directed Peptide Inhibitor

2IPH の概要

• エントリーDOI: 10.2210/pdb2iph/pdb
• 分子名称: Thiol protease P3C, N-ACETYL-L-ALPHA-GLUTAMYL-L-PHENYLALANYL-L-GLUTAMINYL-N-[(1S)-4-AMINO-1-(2-CARBOXYETHYL)-4-OXOBUTYL]-L-LEUCINAMIDE (3 entities in total)
• 機能のキーワード: beta barrel, alpha helix, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Southampton virus (serotype 3)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40078.15

構造登録者

Hussey, R.J. (登録日: 2006-10-12, 公開日: 2007-10-23, 最終更新日: 2012-06-20)

• 主引用文献: Hussey, R.J.,Coates, L.,Gill, R.S.,Erskine, P.T.,Coker, S.F.,Mitchell, E.,Cooper, J.B.,Wood, S.,Broadbridge, R.,Clarke, I.N.,Lambden, P.R.,Shoolingin-Jordan, P.M.; A Structural Study of Norovirus 3C Protease Specificity: Binding of a Designed Active Site-Directed Peptide Inhibitor.; Biochemistry, 50:240-249, 2011; PubMed: 21128685; DOI: 10.1021/bi1008497

実験手法

X-RAY DIFFRACTION (1.75 Å)