2IHQ

Crystal Structure of the Rat Androgen Receptor Ligand Binding Domian Complex with an N-Aryl-Hydroxybicyclohydantoin

Summary for 2IHQ

Entry DOI	10.2210/pdb2ihq/pdb
Related	1I37
Descriptor	Androgen receptor, 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE (3 entities in total)
Functional Keywords	androgen receptor, steroid receptor, nuclear receptor, transcription regulation, ligand-binding domain, hormone-growth factor complex, hormone/growth factor
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Nucleus: P15207
Total number of polymer chains	1
Total formula weight	30589.72
Authors	Sack, J.S. (deposition date: 2006-09-27, release date: 2006-12-12, Last modification date: 2023-08-30)
Primary citation	Sun, C.,Robl, J.A.,Wang, T.C.,Huang, Y.,Kuhns, J.E.,Lupisella, J.A.,Beehler, B.C.,Golla, R.,Sleph, P.G.,Seethala, R.,Fura, A.,Krystek, S.R.,An, Y.,Malley, M.F.,Sack, J.S.,Salvati, M.E.,Grover, G.J.,Ostrowski, J.,Hamann, L.G. Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold. J.Med.Chem., 49:7596-7599, 2006 Cited by PubMed: 17181141 DOI: 10.1021/jm061101w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation