2IGY

Achiral, Cheap and Potent Inhibitors of Plasmepsins II

Summary for 2IGY

Entry DOI	10.2210/pdb2igy/pdb
Related	2BJU 2IGX
Descriptor	Plasmepsin-2, N-[1-(3-METHYLBUTYL)PIPERIDIN-4-YL]-N-{4-[METHYL(PYRIDIN-4-YL)AMINO]BENZYL}-4-PENTYLBENZAMIDE (3 entities in total)
Functional Keywords	achiral inhibitor, hydrolase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Cellular location	Vacuole: P46925
Total number of polymer chains	2
Total formula weight	74989.03
Authors	Prade, L. (deposition date: 2006-09-25, release date: 2006-11-28, Last modification date: 2024-11-20)
Primary citation	Boss, C.,Corminboeuf, O.,Grisostomi, C.,Meyer, S.,Jones, A.F.,Prade, L.,Binkert, C.,Fischli, W.,Weller, T.,Bur, D. Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV. Chemmedchem, 1:1341-1345, 2006 Cited by PubMed: 17091526 DOI: 10.1002/cmdc.200600223 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation