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2IEO

Crystal structure analysis of HIV-1 protease mutant I84V with a potent non-peptide inhibitor (UIC-94017)

Replaces:  1S6S
Summary for 2IEO
Entry DOI10.2210/pdb2ieo/pdb
Related2IDW 2IEN
DescriptorProtease, CHLORIDE ION, SODIUM ION, ... (5 entities in total)
Functional Keywordshiv-1 protease, mutant, i84v, dimer, inhibitor, uic-94017, tmc114, darunavir, hydrolase
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22130.31
Authors
Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Manna, D.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-09-19, release date: 2006-10-03, Last modification date: 2023-08-30)
Primary citationTie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T.
High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338:341-352, 2004
Cited by
PubMed: 15066436
DOI: 10.1016/j.jmb.2004.02.052
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.53 Å)
Structure validation

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