2IDW

Crystal structure analysis of HIV-1 protease mutant V82A with a potent non-peptide inhibitor (UIC-94017)

Replaces:  1S65

Summary for 2IDW

Related2IEN 2IEO
DescriptorProtease, CHLORIDE ION, PHOSPHATE ION, ... (8 entities in total)
Functional Keywordshiv-1 protease, mutant, dimer, inhibitor, uic-94017, hydrolase
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total molecular weight22918.79
Authors
Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Manna, D.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2006-09-15, release date: 2006-10-03, Last modification date: 2017-10-18)
Primary citation
Tie, Y.,Boross, P.I.,Wang, Y.F.,Gaddis, L.,Hussain, A.K.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T.
High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338:341-352, 2004
PubMed: 15066436 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2004.02.052
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.1 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1511700.6%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2idw
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Molmil generated image of 2idw
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Molmil generated image of 2idw
rotated about y axis by 90°