Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 501 |
| Chain | Residue |
| A | GLY73 |
| A | THR74 |
| A | ASN88 |
| A | HOH1163 |
| A | HOH1237 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PO4 A 701 |
| Chain | Residue |
| A | HOH1013 |
| A | HOH1057 |
| A | HOH1063 |
| A | HOH1247 |
| A | HOH1262 |
| B | LYS114 |
| B | GLY117 |
| B | ACY606 |
| B | HOH1154 |
| A | LYS14 |
| A | ILE15 |
| A | GLY16 |
| A | GLY17 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 702 |
| Chain | Residue |
| A | PRO39 |
| A | GLY40 |
| A | HOH1115 |
| A | HOH1270 |
| B | MET136 |
| B | SER137 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 703 |
| Chain | Residue |
| B | PRO101 |
| B | ARG157 |
| B | HIS169 |
| B | HOH1049 |
| B | HOH1133 |
| B | HOH1210 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 704 |
| Chain | Residue |
| A | LYS20 |
| A | GLU21 |
| A | GLU34 |
| A | ARG41 |
| A | ASN83 |
| A | HOH1136 |
| A | HOH1164 |
| A | HOH1266 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 017 B 401 |
| Chain | Residue |
| A | ASP25 |
| A | GLY27 |
| A | ALA28 |
| A | ASP30 |
| A | VAL32 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | PRO81 |
| A | ILE84 |
| B | ASP125 |
| B | GLY127 |
| B | ALA128 |
| B | ASP129 |
| B | ASP130 |
| B | GLY148 |
| B | GLY149 |
| B | ILE150 |
| B | HOH1001 |
| B | HOH1138 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DMS A 901 |
| Chain | Residue |
| A | PRO1 |
| A | LYS55 |
| A | ACY605 |
| A | HOH1248 |
| B | GLY168 |
| B | HIS169 |
| B | LYS170 |
| B | HOH1121 |
| B | HOH1225 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY A 601 |
| Chain | Residue |
| A | MET36 |
| A | SER37 |
| B | PRO139 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACY B 602 |
| Chain | Residue |
| A | GLN92 |
| B | GLY149 |
| B | HOH1214 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACY B 603 |
| Chain | Residue |
| A | TRP6 |
| B | THR191 |
| B | GLY194 |
| B | HOH1025 |
| B | HOH1205 |
| B | HOH1230 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACY B 604 |
| Chain | Residue |
| B | LEU110 |
| B | VAL111 |
| B | THR112 |
| B | GLU121 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACY A 605 |
| Chain | Residue |
| A | MET46 |
| A | PHE53 |
| A | LYS55 |
| A | DMS901 |
| A | HOH1012 |
| B | HOH1121 |
| B | HOH1225 |
| site_id | BC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACY B 606 |
| Chain | Residue |
| A | LYS14 |
| A | LYS70 |
| A | PO4701 |
| A | HOH1247 |
| B | LYS114 |
| B | LYS155 |
| B | GLU165 |
| B | HOH1154 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 801 |
| Chain | Residue |
| A | PRO44 |
| A | VAL56 |
| A | HOH1032 |
| A | HOH1058 |
| B | HOH1052 |
| A | TRP42 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI |
| Chain | Residue | Details |
| A | ALA22-ILE33 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | Region: {"description":"Dimerization of protease","evidences":[{"source":"UniProtKB","id":"P04585","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For protease activity; shared with dimeric partner","evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12924029","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | THR26 | |
| B | THR126 | |
| B | ASP125 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a30 |
| Chain | Residue | Details |
| A | ASP25 | |
| B | ASP125 | |
