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2IBT

Crystal structure of the adenine-specific DNA methyltransferase M.TaqI complexed with the cofactor analog AETA and a 10 bp DNA containing 2-aminopurine at the target position and an abasic site analog at the target base partner position

Summary for 2IBT
Entry DOI10.2210/pdb2ibt/pdb
Related1AQI 1AQJ 1G38 2ADM 2IBS
Descriptor5'-D(*GP*TP*TP*CP*GP*(2PR)P*TP*GP*TP*C)-3', 5'-D(*GP*AP*CP*AP*(3DR)P*CP*GP*(6MA)P*AP*C)-3', Modification methylase TaqI, ... (6 entities in total)
Functional Keywordsdna, dna methyltransferase, 2-aminopurine, abasic site analog, base flipping, nucleotide flipping, transferase-dna complex, transferase/dna
Biological sourceThermus aquaticus
More
Total number of polymer chains6
Total formula weight109117.70
Authors
Lenz, T.,Scheidig, A.J.,Weinhold, E. (deposition date: 2006-09-12, release date: 2007-05-29, Last modification date: 2023-10-25)
Primary citationLenz, T.,Bonnist, E.Y.M.,Pljevaljcic, G.,Neely, R.K.,Dryden, D.T.F.,Scheidig, A.J.,Jones, A.C.,Weinhold, E.
2-Aminopurine Flipped into the Active Site of the Adenine-Specific DNA Methyltransferase M.TaqI: Crystal Structures and Time-Resolved Fluorescence
J.Am.Chem.Soc., 129:6240-6248, 2007
Cited by
PubMed: 17455934
DOI: 10.1021/ja069366n
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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