Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0006304 | biological_process | DNA modification |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009007 | molecular_function | site-specific DNA-methyltransferase (adenine-specific) activity |
| A | 0009307 | biological_process | DNA restriction-modification system |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0043412 | biological_process | macromolecule modification |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0003677 | molecular_function | DNA binding |
| D | 0006304 | biological_process | DNA modification |
| D | 0008168 | molecular_function | methyltransferase activity |
| D | 0009007 | molecular_function | site-specific DNA-methyltransferase (adenine-specific) activity |
| D | 0009307 | biological_process | DNA restriction-modification system |
| D | 0016740 | molecular_function | transferase activity |
| D | 0032259 | biological_process | methylation |
| D | 0043412 | biological_process | macromolecule modification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE NEA A 2001 |
| Chain | Residue |
| A | VAL21 |
| A | ASN105 |
| A | PRO107 |
| A | PHE146 |
| A | GOL3002 |
| A | HOH3163 |
| A | HOH3189 |
| A | HOH3200 |
| A | HOH3277 |
| A | HOH3305 |
| A | ALA47 |
| A | GLU71 |
| A | ILE72 |
| A | ASP73 |
| A | ALA76 |
| A | ALA88 |
| A | ASP89 |
| A | PHE90 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NEA D 2002 |
| Chain | Residue |
| D | VAL21 |
| D | ALA47 |
| D | GLU71 |
| D | ILE72 |
| D | ASP73 |
| D | ALA76 |
| D | ALA88 |
| D | ASP89 |
| D | PHE90 |
| D | ASN105 |
| D | PRO107 |
| D | PHE146 |
| D | GOL3003 |
| D | HOH3109 |
| D | HOH3170 |
| D | HOH3243 |
| D | HOH3297 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 3001 |
| Chain | Residue |
| A | GLU317 |
| A | HOH3195 |
| A | HOH3313 |
| A | HOH3332 |
| A | HOH3384 |
| D | ALA233 |
| D | GLU234 |
| D | TYR235 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 3002 |
| Chain | Residue |
| A | TYR129 |
| A | LEU142 |
| A | NEA2001 |
| A | HOH3273 |
| A | HOH3411 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 3003 |
| Chain | Residue |
| D | ILE72 |
| D | TYR129 |
| D | LEU142 |
| D | NEA2002 |
| D | HOH3165 |
| D | HOH3359 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL D 3004 |
| Chain | Residue |
| D | ARG42 |
| D | ARG66 |
| D | GLU84 |
| D | ILE86 |
| D | PRO95 |
| D | HOH3072 |
| D | HOH3222 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 3005 |
| Chain | Residue |
| A | HIS278 |
| A | PRO279 |
| A | GLU321 |
| D | PRO81 |
| D | GOL3006 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 3006 |
| Chain | Residue |
| A | LYS277 |
| D | ARG58 |
| D | THR63 |
| D | TYR65 |
| D | PHE67 |
| D | TRP82 |
| D | GOL3005 |
| D | HOH3228 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 3007 |
| Chain | Residue |
| A | TYR191 |
| A | LEU192 |
| A | ASP219 |
| A | THR220 |
| A | GLN221 |
| A | GLU222 |
| A | ARG389 |
| A | HOH3034 |
| A | HOH3439 |
| A | HOH3440 |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. ILGNPPY |
| Chain | Residue | Details |
| A | ILE102-TYR108 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | THR23 | |
| D | PRO107 | |
| A | GLU45 | |
| A | GLU71 | |
| A | ASP89 | |
| A | PRO107 | |
| D | THR23 | |
| D | GLU45 | |
| D | GLU71 | |
| D | ASP89 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Important for catalytic activity => ECO:0007744|PDB:2ADM |
| Chain | Residue | Details |
| A | ASN105 | |
| A | TYR108 | |
| D | ASN105 | |
| D | TYR108 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Important for catalytic activity; via amide nitrogen => ECO:0007744|PDB:2ADM |
| Chain | Residue | Details |
| A | PRO106 | |
| D | PRO106 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 46 |
| Chain | Residue | Details |
| A | ASN105 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | PRO106 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR108 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | PHE196 | steric role |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 46 |
| Chain | Residue | Details |
| D | ASN105 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| D | PRO106 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| D | TYR108 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| D | PHE196 | steric role |
